| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800726 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2012 | 13 Pages |
Abstract
⺠MD-refined P450 structures identify the importance of channels in CYP3A4 docking. ⺠A unique configuration is identified involving Arg212 in the dehydrogenation of 4OHT. ⺠CYP3A4 and CYP3A4-R212A show a decreased rate of dehydrogenation versus oxygenation.
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Authors
Kiumars Shahrokh, Thomas E. III, Garold S. Yost,