Î²-Glucan from Saccharomyces cerevisiae reduces lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages

Article ID	Journal	Published Year	Pages	File Type
10800731	Biochimica et Biophysica Acta (BBA) - General Subjects	2012	8 Pages	PDF

Abstract

âº Baker's yeast Î²-glucan inhibited LPS-induced NO production in mouse MÏ. âº Î²-glucan suppressed both MAPK and TLR2 pathways. âº Dectin-1 was not involved in the inhibitory effects of Î²-glucan on NO production.

Keywords

sICAM-1 ERK iNOS GM-CSF CCL CXCL Hprt M-CSF cNOS BLC BBG RAW264.7 macrophage CC chemokine ligands I-TAC TNF thymus and activation regulated chemokine B-lymphocyte chemoattractant MIP LPS DMEM SDS Jnk FBS MCP RT-PCR SDF c-Jun N-terminal kinase MAPK MIG Dulbecco's modified Eagle's medium NFκB interleukin Beta-glucan TIMP TARC sodium dodecyl sulfate fetal bovine serum inducible nitric oxide synthase constitutive nitric oxide synthase Anti-inflammation Stromal cell-derived factor granulocyte-macrophage colony-stimulating factor granulocyte colony-stimulating factor G-CSF tumor necrosis factor nuclear factor κB TREM lipopolysaccharide macrophage colony-stimulating factor Complement RANTES soluble intercellular adhesion molecule Nitric oxide reverse transcription-polymerase chain reaction macrophage inflammatory protein monocyte chemoattractant protein mitogen-activated protein kinase Keratinocyte chemoattractant extracellular signal-regulated kinase triggering receptor expressed on myeloid cells

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Î²-Glucan from Saccharomyces cerevisiae reduces lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages

Authors

Xiaojuan Xu, Michiko Yasuda, Masashi Mizuno, Hitoshi Ashida,