Article ID Journal Published Year Pages File Type
10800744 Biochimica et Biophysica Acta (BBA) - General Subjects 2012 12 Pages PDF
Abstract
► Reduced AGEF-1 levels in C. elegans results in Cup and lysosomal enlargement in CC. ► ARL-8 functions upstream of AGEF-1 in lysosomes but downstream in uptake. ► AGEF-1 may function in lysosomes independent of its ARF exchange activity. ► ARF-1 and ARF-3 are candidate proteins as AGEF-1 substrates for the Cup defect.
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