| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800756 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2012 | 7 Pages |
Abstract
⺠We monitored the UPR in liver and myocardium, tissues that differ in O2 requirement. ⺠Mice exposure to 6.5% O2 resulted in ATF4, CHOP and GADD34 activation in liver. ⺠In the myocardium the ATF4-CHOP-GADD34 markers were not detectably activated. ⺠The apoptotic pathway mediated by CHOP and p-JNK was activated in hepatocytes only. ⺠Hepatocytes and myocites fine tune the UPR signaling pathway in in vivo hypoxia.
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Authors
Luigina Tagliavacca, Anna Caretti, Paola Bianciardi, Michele Samaja,