| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800765 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2012 | 8 Pages |
Abstract
⺠We designed and synthesized 3-DBP as a potent tyrosinase inhibitor. ⺠The depigmenting effect of 3-DBP was resulted from inhibition of tyrosinase non-competitively. ⺠3-DBP suppressed α-MSH induced melanin synthesis in B16 melanoma cells. ⺠3-DBP showed great efficiency in reducing UVB-induced melanin synthesis in HRM2 hairless mouse in vivo model. ⺠3-DBP can be an effective skin-whitening agent.
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Authors
Ki Wung Chung, Yun Jung Park, Yeon Ja Choi, Min Hi Park, Young Mi Ha, Yohei Uehara, Jung Hyun Yoon, Pusoon Chun, Hyung Ryong Moon, Hae Young Chung,