TF - A novel cell-permeable and selective inhibitor of human protein kinase CK2 induces apoptosis in the prostate cancer cell line LNCaP

► A new dibenzofuranone derivative (TF) is a selective inhibitor of the kinase CK2. ► TF is characterized by low IC50 (29 nM) and Ki (15 nM) values. ► TF is effective in strongly reducing cell viability of prostate cancer cells. ► TF is a new lead structure for the development of more effective inhibitors.