| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800777 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2012 | 8 Pages |
Abstract
⺠Nicotine induces the translation of GluR2 mRNA through α7-nAChR in NG108-15 cells. ⺠A transient increase of YB-1/HSP60 interaction is observed in nicotine-treated cells. ⺠PI3K/Akt pathway is necessary for translational increase and YB-1/HSP60 interaction. ⺠Neural activity alters the molar ratio of YB-1 bound to GluR2 mRNA in polysomes. ⺠In HSP60-decreased cells, YB-1 nuclear localization occurs with nicotine treatment.
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Authors
Toru Tanaka, Sachiyo Ohashi, Masamitsu Moue, Shunsuke Kobayashi,