Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin

Article ID	Journal	Published Year	Pages	File Type
10800784	Biochimica et Biophysica Acta (BBA) - General Subjects	2012	11 Pages	PDF

Abstract

âº Apigenin protected BNLCL2 cells against oxidative damage. âº Apigenin induced HNSCC cell apoptosis via TNF-R and TRAIL-R signaling pathways. âº Apigenin induced cell apoptosis by generating oxidative stress. âº The combinatory use of apigenin with 5-Fu or cisplatin accelerated apoptotic cell death.

Keywords

EGFR NF-κB 5-FU TRAIL-R HNSCC TNF-R ROS Apigenin cisplatin nuclear transcription factor kappa B 5-fluorouracil Reactive oxygen species Epidermal growth factor receptor tumor necrosis factor receptor death receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin

Authors

Leong-Perng Chan, Tzung-Han Chou, Hsiou-Yu Ding, Pin-Ru Chen, Feng-Yu Chiang, Po-Lin Kuo, Chia-Hua Liang,