Article ID Journal Published Year Pages File Type
10800787 Biochimica et Biophysica Acta (BBA) - General Subjects 2012 9 Pages PDF
Abstract
► Mitochondrial dysfunction-generated ROS promotes gastric cancer cell migration. ► Mitochondrial dysfunction-generated ROS increases β5-integrin protein expression. ► β5-integrin upregulation is required for the enhanced migration. ► Migratory cells exhibit mitochondrial dysfunction and high β5-integrin expression. ► Gastric cancers with higher β5-integrin expression show more aggressive behavior.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Mitochondrial dysfunction promotes cell migration via reactive oxygen species-enhanced β5-integrin expression in human gastric cancer SC-M1 cells
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