Article ID Journal Published Year Pages File Type
10800793 Biochimica et Biophysica Acta (BBA) - General Subjects 2012 8 Pages PDF
Abstract
► Two carcinoma cells, HCT116 and MCF7, have similar GSL profile and Gb4 is one of the major neutral GSL. ► The depletion of total GSL suppressed cell proliferation and RTK-induced ERK signaling. ► Exogeneous addition of Gb4 restored phosphorylation of EGFR and ERK. ► Gb4 forms a complex with EGFR.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor
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