| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800795 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2012 | 9 Pages |
Abstract
⺠Inhibition of cell growth by 5-epi-sinuleptolide exceeded that by sinuleptolide. ⺠5-epi-sinuleptolide inhibited G2/M phase regulators of cyclin B1 and CDK1. ⺠5-epi-Sinuleptolide induced SCC25 cells apoptosis by TNFR and Fas-mediated pathways. ⺠5-epi-Sinuleptolide induced apoptosis via mitochondria-mediated caspase pathway.
Keywords
5-FUTNF-receptorTNF-RNMSCTRADDCDK1FADDAPAf-1BCCRT-PCRDMEMSCCPBSFBS3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideDMSODulbecco's modified Eagle MediumMTTapoptotic protease activating factor-1tBidtumor necrosis factor-αFas-associated death domainDimethyl sulfoxideSkin cancerfetal bovine serumFas LigandFasLTNF-α5-fluorouracilPhosphate-buffered salinereverse transcription-polymerase chain reactionBasal cell carcinomaSquamous cell carcinomaCyclin-dependent kinase 1death receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Chia-Hua Liang, Guey-Horng Wang, Tzung-Han Chou, Shih-Hao Wang, Rong-Jyh Lin, Leong-Perng Chan, Edmund Cheung So, Jyh-Horng Sheu,