The transferrin receptor and the targeted delivery of therapeutic agents against cancer

Article ID	Journal	Published Year	Pages	File Type
10800817	Biochimica et Biophysica Acta (BBA) - General Subjects	2012	27 Pages	PDF

Abstract

âº Summary of delivery strategies targeting the transferrin receptor. âº Summary of complexes with targeting moiety directly conjugated to the therapeutic. âº Summary of approaches where targeted carriers are loaded with the therapeutic.

Keywords

PEI PLGA pDNA DAB TNFα MCC IFN-α CMC PCL CTL TFR Transferrin CDP PLA GFP eGFP scFv IC50 shRNA PPI BAP GCV HUVEC i.p.DMS RES PNP GBM IL-2 ODN HIF-1α PTX PGP GM-CSF i.v.s.c.DMT1 PAP ADR MCV MDR-1 Mitomycin C BTB Rta VSV-G HVJ-E BFU-E CFU-GM EDN CFU-E DOTAP ID50 Oligonucleotides ADEPT HSV-tk DDAB dihydroartemisinin Pseudomonas exotoxin TPL colony forming unit-erythroid Dimethylsuberimidate vesicular stomatitis virus G protein P-glycoprotein short hairpin RNA siRNA Adamantane Artemisinin Avidin Immunotoxin Interferon-α Interleukin-2 Cho EPR tumor necrosis factor α diphtheria toxin intraperitoneal Intravenous Antibody-directed enzyme prodrug therapy DHA dimethyldioctadecylammonium bromide Delivery subcutaneous BBB Blood–brain barrier Cancer Human umbilical vein endothelial cells Chinese hamster ovary cells Reticuloendothelial system cyclodextrins hypoxia inducible factor-1α granulocyte-macrophage colony-stimulating factor critical micelle concentration cytotoxic T lymphocyte Blood–tumor barrier Divalent metal transporter 1 MHC major histocompatibility complex Conjugate Nanoparticle nanometer Enhanced permeability and retention Eosinophil-derived neurotoxin Gallium nitrate ART Herpes simplex virus thymidine kinase RIP PAMAM Paclitaxel Green fluorescence protein enhanced green fluorescence protein Multidrug resistance protein-1 Platinum Plasmid DNA poly(lactic-co-glycolic) acid Poly(lactic) acid Poly(propyleneimine)Poly(ε-caprolactone)Polyamidoamine polyethylene glycol polyethyleneimine PEG Purine nucleoside phosphorylase DOPE Chitosan Gancyclovir Glioblastoma multiforme transferrin receptor