Connecting genotype to phenotype in the era of high-throughput sequencing

► Scalable annotation and curation of genomic data is becoming a necessity. ► A controlled vocabulary for annotation facilitates the phenotype inference process. ► Phenotype inference methods enable the correction of underlying annotations. ► The growth in reference genomes is enhancing annotation and phenotype inference. ► The SEED Project provides integrated tools for predicting phenotype from genotype.