| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800854 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2011 | 7 Pages |
Abstract
⺠In the present study, we characterized a STAS-domain amino acid mutation of SLC26A9 having a significant impact on ion transport. ⺠This mutation was found to reduce Clâ transport through SLC26A9 as well as the positive interaction exerted by SLC26A9 on CFTR ion transport activity. ⺠This study strengthens the role of the STAS domain in channel function as accounted for its interaction or stabilization of CFTR. ⺠SLC26A9 mutations in the STAS domain may be associated with some “cystic fibrosis-like” patient phenotypes that do not imply a CFTR gene defect.
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Authors
Martine Avella, Franck Borgese, Jordi Ehrenfeld,