Analogs of 5-(substituted benzylidene)hydantoin as inhibitors of tyrosinase and melanin formation

Article ID	Journal	Published Year	Pages	File Type
10800859	Biochimica et Biophysica Acta (BBA) - General Subjects	2011	8 Pages	PDF

Abstract

âº A series of 5-(substituted benzylidene)hydantoin derivatives were synthesized. âº We examine the inhibitory activities toward melanin formation of the compounds. âº Increasing information will contribute to the development of effective drugs.

Keywords

NaOAc Antimelanogenesis CaH2 PBS TLC DMEM FBS AcOH CDCl3 PDB NMDA N-methyl-d-aspartic acid HCl nuclear magnetic resonance 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide DMSO l-3,4-dihydroxyphenylalanine l-DOPA Dulbecco's modified Eagle's medium MTT Sodium acetate Acetic acid analysis of variance ANOVA NMR Carbon dioxide Dimethyl sulfoxide fetal bovine serum Tyrosinase inhibitory activity Phosphate-buffered saline Protein Data Bank CO2 thin-layer chromatography Deuterated chloroform Hydrogen chloride Calcium hydride

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Analogs of 5-(substituted benzylidene)hydantoin as inhibitors of tyrosinase and melanin formation

Authors

Young Mi Ha, Jin-Ah Kim, Yun Jung Park, Daeui Park, Ji Min Kim, Ki Wung Chung, Eun Kyeong Lee, Ji Young Park, Ji Yeon Lee, Hye Jin Lee, Jeong Hyun Yoon, Hyung Ryong Moon, Hae Young Chung,