| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800881 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2011 | 10 Pages |
Abstract
⺠Acridine derivatives affect amyloid aggregation of lysozyme. ⺠Extent of amyloid inhibition and depolymerization depends on acridine structure. ⺠Planarity and tautomerism of 9-aminoacridine core enhance anti-amyloid activity. ⺠IC50 and DC50 for most effective planar acridines at low micromolar concentrations. ⺠Identification of acridines with high antiamyloid activity and low cytotoxicity.
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Authors
Andrea Antosova, Beatrice Chelli, Eva Bystrenova, Katarina Siposova, Francesco Valle, Jan Imrich, Maria Vilkova, Pavol Kristian, Fabio Biscarini, Zuzana Gazova,