| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800889 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2011 | 9 Pages |
Abstract
⺠Both Rac1 and Rac2 but not CDC42 or RhoA are activated in LPS-challenged lung injury. ⺠Activation of Rac is important in lung injury, as evidenced by using Rac inhibitor. ⺠Inhibition of Rac attenuates injury through decreasing migration and permeability. ⺠Rac could be a potential target for therapeutic intervention of pulmonary inflammation.
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Authors
Hong-yi Yao, Lihua Chen, Chengyun Xu, Jirong Wang, Jiqiang Chen, Qiang-min Xie, Ximei Wu, Xiao-feng Yan,