| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800893 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2011 | 9 Pages |
Abstract
⺠Two types of propolis components inhibit downregulation of adiponectin via different mechanisms. ⺠Artepillin C (C3) functions as a PPARγ agonist. ⺠C3 can form a stable complex with the hPPARγ LBD based on molecular docking studies. ⺠C4 is an effective inhibitor of JNK activation. The predicted binding mode of C4 was similar to the binding modes of known JNK inhibitors.
Keywords
PPARc-Jun-NH2-terminal kinaseMM-PBSATZDAP2TTBSEMMFBSJnkMolecular mechanics Poisson-Boltzmann surface areaMAPKMKKvdWAdipocyteadiponectinTroglitazonetumor necrosis factor-αfetal bovine serumTNF-αVan der Waalsmitogen-activated protein kinasemitogen-activated protein kinase kinasepropolisperoxisome proliferator-activated receptor
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Authors
Rie Ikeda, Masayoshi Yanagisawa, Nobuyuki Takahashi, Teruo Kawada, Shigenori Kumazawa, Noriyuki Yamaotsu, Izumi Nakagome, Shuichi Hirono, Takanori Tsuda,