Mannose 6-phosphate receptor homology (MRH) domain-containing lectins in the secretory pathway

Article ID	Journal	Published Year	Pages	File Type
10800899	Biochimica et Biophysica Acta (BBA) - General Subjects	2011	12 Pages	PDF

Abstract

âº Recycling receptors, ER proteins, and a glycosyltransferase contain MRH domain. âº Many MRH domains function as lectins and bind mannose-containing N-glycans. âº Structures are known for ten MRH domains, revealing conservation of a similar fold. âº OS-9 and the MPR use the same four residues (Gln, Arg, Glu, Tyr) to bind mannose.

Keywords

TGN CD-MPR Man-6-P TGF-β LIF Mucolipidosis II MRH CI-MPR IGF-II LSD ERAD GAA MPR Lysosomal storage disorder Acid α-glucosidase Insulin-like growth factor-II Endoplasmic reticulum associated degradation SPR Surface plasmon resonance Trans Golgi Network endoplasmic reticulum Carbohydrate recognition leukemia inhibitory factor Lectin mannose 6-phosphate Secretory pathway Protein targeting Mannose 6-phosphate receptor