| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800909 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2011 | 9 Pages |
Abstract
⺠Structural and energetic consequences of the mutational exchange of a residue in the speciï¬city pocket of aldose reductase. ⺠Study by high resolution crystallography and isothermal titration calorimetry. ⺠Three carboxylate-type inhibitors investigated, one with speciï¬city pocket in closed, two in opened state. ⺠Inhibitor induced-ï¬t adaptations provoke the transition into another crystal form. ⺠New crystal form avoids packing contacts to the crucially affected residues.
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Authors
Cornelia Koch, Andreas Heine, Gerhard Klebe,