Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10800920 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2009 | 6 Pages |
Abstract
Cationic lipids have been extensively used as carriers of biologically active molecules (nucleic acids, peptides and proteins) into cells. Recent data provided evidence that cationic lipids are not just inert transporters but do activate specific cellular cascades. This review illustrates these activating properties with a few examples. Cell activation raises the question of which receptors are involved. Some cationic lipids seem to satisfy specific structural requirements of Toll-like receptors (TLR4) as they activate TLR4-dependent pathways. However, cationic lipids display a large structural diversity and it is likely that they are also recognized by receptors with a broader specificity. Alternatives are proposed and discussed to explain this broad specificity.
Keywords
DOTAPTLRPKCGPiIKKTABIKBIRF3IP-10Jun N-terminal kinasePI-3KTRAFMD-2ERK 1/2DMPGDDABdimyristoyl-phosphatidylcholineIL-1R-associated kinaseDiC14-amidineInhibitor of nuclear factor-κBTAK1-binding proteinTBKTAKIκB-kinase1,2-dioleoyl-3-trimethylammoniumpropanedimyristoyl-phosphatidylglycerolLPSJnkEPCMYD88NF-kBLBPSRCMCP-1PLCAP-1IP3dMPCInositol 1,4,5-triphosphateMAPKMAPK/ERK kinaseTRIFImmunostimulatorytumor necrosis factor-αTANK-binding kinase 1Toll-like receptordiacylglycerolDioctadecyldimethylammonium bromideDAGCell signalingAnti-inflammatoryTAPmyeloid differentiation factor 88Interferon regulatory factor 3IRAKtumor necrosis factor receptor associated factor 6TNF-αnuclear factor kappa BPhosphoinositide kinasephospholipase CLipofectamineLipopolysaccharidesCationic lipidMEKlipopolysaccharide binding proteinMyeloid differentiation protein-2monocyte chemoattractant protein-1activator protein 1Protein kinase Cmitogen activated protein kinaseextracellular-signal-regulated kinase 1/2Receptor
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Authors
Caroline Lonez, Marc F. Lensink, Michel Vandenbranden, Jean-Marie Ruysschaert,