Lovastatin protects keratinocytes from DNA damage-related pro-apoptotic stress responses stimulated by anticancer therapeutics

Article ID	Journal	Published Year	Pages	File Type
10801825	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	2016	11 Pages	PDF

Abstract

Lovastatin attenuates pro-toxic DNA damage-related responses of keratinocytes stimulated by OM-inducing anticancer therapeutics. The data encourage forthcoming in vivo and clinical studies addressing the usefulness of statins in the prevention of OM.

Keywords

KAP1 RPA SSB γH2AX SAPK PARP 53BP1 DNA-PKcs DDR DNA damage response (DDR)ATR Jnk ataxia telangiectasia and Rad3-related DSB 5-FU PI3K NF-κB KRAB-associated protein 1 ataxia telangiectasia mutated c-Jun N-terminal kinase ROS Anthracyclines Statins stress activated protein kinase checkpoint kinase ionizing radiation DNA repair replication protein A ATM Doxo Doxorubicin DNA double-strand break DNA single-strand break LOVA nuclear factor kappaB Phosphatidylinositol 3-kinase 5-fluorouracil Cell death Oral mucositis Hydroxyurea DNA damage response Poly(ADP-ribose) polymerase Chk Keratinocytes Reactive oxygen species