Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10802113 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2014 | 14 Pages |
Abstract
In conclusion: 1) SERCA2a is the major isoform in both cardiac and vascular myocytes; 2) the expression of SERCA2a mRNA is ~Â 30 fold higher in the heart compared to vascular tissues; and 3) nearly half the amount of SERCA2a mRNA is measured in both failing cardiomyocytes and synthetic VSMCs compared to healthy tissues, with a relocation of SERCA2a in failing cardiomyocytes. Thus, SERCA2a is the principal regulator of excitation-contraction coupling in both CMs and contractile VSMCs.
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Authors
Larissa Lipskaia, Zela Keuylian, Karl Blirando, Nathalie Mougenot, Adeline Jacquet, Clotilde Rouxel, Haifa Sghairi, Ziane Elaib, Regis Blaise, Serge Adnot, Roger J. Hajjar, Elie R. Chemaly, Isabelle Limon, Regis Bobe,