| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802253 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2014 | 7 Pages |
Abstract
Overall these data confirm that HPSE is a key player in renal fibrosis since it interacts with the regulation and the effects of TGF-β. HPSE is needed for pathological TGF-β overexpression in response to pro-fibrotic factors. Furthermore, HPSE modulates TGF-β-induced EMT: the lack of HPSE delays tubular cell transdifferentiation, and impairs the TGF-β autocrine loop.
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Authors
Valentina Masola, Gianluigi Zaza, Maria Francesca Secchi, Giovanni Gambaro, Antonio Lupo, Maurizio Onisto,