| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802315 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 13 Pages |
Abstract
⺠The calcium-sensing receptor (CaSR) is a key controller for Ca2 +o levels ⺠The CaSR is associated with both anti- and pro-proliferative signals ⺠Altered CaSR expression/signalling is associated with some forms of cancer ⺠A systems biology approach may help unravel CaSR-mediated signalling/interactions ⺠Targeting the CaSR may lead to novel cancer therapeutics
Keywords
caudal type homeobox 2pTHMAP kinase kinaseWntCaSRPKCVDREGEFPTHrPPLCGPCRRor2IP3APCreceptor activator of NFκB ligandCDX-2TGF-βERKRGS5SDF-1RANKLreceptor activator of NFκBbFGFEGFPHPTNFκBParathyroid adenomaadenomatous polyposis coliSTATWinglessTransforming Growth Factor BetaRankSystems biologyColorectal cancerProstate cancerBreast cancerepidermal growth factorstromal cell-derived factor 1vitamin D responsive elementguanine nucleotide exchange factorbasic fibroblast growth factornuclear factor-kappaBphospholipase Csignal transducers and activators of transcriptionMEKmapparathyroid hormonePrimary hyperparathyroidismmitogen-activated proteinProtein kinase Cparathyroid hormone related peptideExtracellular calciumIntracellular calciumextracellular-signal-regulated kinaseCalcium sensing receptorG protein-coupled receptor
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Authors
Sarah C. Brennan, Ursula Thiem, Susanne Roth, Abhishek Aggarwal, Irfete Sh. Fetahu, Samawansha Tennakoon, Ana Rita Gomes, Maria Luisa Brandi, Frank Bruggeman, Romuald Mentaverri, Daniela Riccardi, Enikö Kallay,