Article ID Journal Published Year Pages File Type
10802330 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2013 12 Pages PDF
Abstract
► This review describes the discovery of the mitochondria-associated membrane (MAM). ► The MAM accommodates lipid metabolism, but also ER-mitochondria calcium signaling. ► Oxidoreductases (e.g. Ero1α) and chaperones (e.g. calnexin) regulate MAM signaling. ► Targeting to the MAM depends on redox, phosphorylation or palmitoylation. ► MAM tethers play important roles in neurodegenerative diseases.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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