| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802334 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 9 Pages |
Abstract
⺠RAGE is a multiligand receptor involved in inflammation, diabetes, atherosclerosis, neurodegeneration and cancer. ⺠RAGE transduces effects of AGEs, HMGB1, β-amyloid fibrils, certain S100 proteins, and DNA and RNA in several cell types. ⺠Adaptor proteins associate with RAGE's cytoplasmic domain resulting in signaling. ⺠However, RAGE is also involved in tissue homeostasis and regeneration upon acute injury, and in resolution of inflammation.
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Authors
Guglielmo Sorci, Francesca Riuzzi, Ileana Giambanco, Rosario Donato,