Article ID Journal Published Year Pages File Type
10802335 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2013 18 Pages PDF
Abstract
► Cbl-family ubiquitin ligases function as negative regulators of PTK signaling ► Recruitment and activation mechanisms ensure Cbl selectivity for activated PTKs ► Cbl-dependent ubiquitination regulates PTK degradation in lysosome and proteasome ► Genetic studies demonstrate essential roles of Cbl proteins in physiological pathways ► Mutational inactivation of Cbl is causally linked to human leukemia
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Authors
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