Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10802335 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 18 Pages |
Abstract
⺠Cbl-family ubiquitin ligases function as negative regulators of PTK signaling ⺠Recruitment and activation mechanisms ensure Cbl selectivity for activated PTKs ⺠Cbl-dependent ubiquitination regulates PTK degradation in lysosome and proteasome ⺠Genetic studies demonstrate essential roles of Cbl proteins in physiological pathways ⺠Mutational inactivation of Cbl is causally linked to human leukemia
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Authors
Bhopal Mohapatra, Gulzar Ahmad, Scott Nadeau, Neha Zutshi, Wei An, Sarah Scheffe, Lin Dong, Dan Feng, Benjamin Goetz, Priyanka Arya, Tameka A. Bailey, Nicholas Palermo, Gloria E.O. Borgstahl, Amarnath Natarajan, Srikumar M. Raja, Mayumi Naramura,