| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802336 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 10 Pages |
Abstract
⺠Endogenous TG2 suppresses HIF activity. ⺠Nuclear localization of TG2 is necessary for suppression of HIF activity. ⺠Interaction between TG2 and HIF1β is not required for HIF activity suppression. ⺠TG2 is found on HIF target promoters in hypoxia. ⺠Conformation of TG2 is crucial in determining the fate of the cell in ischemia.
Keywords
nESXRECATDFODesferrioxamineTG2shRNAHEKHREHIFNLSOGDshort hairpin RNAIschemiachromatin immunoprecipitationTransglutaminase 2Transcriptionnuclear export signalnuclear localization signalxenobiotic response elementhypoxia response elementHypoxia Inducible FactorOxygen glucose deprivationCell deathHypoxiaCHiPCatalytichuman embryonic kidney
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Authors
Soner Gundemir, Gozde Colak, Julianne Feola, Richard Blouin, Gail V.W. Johnson,