| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802341 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 10 Pages |
Abstract
⺠We firstly demonstrated the critical role of PARP-1 in low shear stress induced inflammation. ⺠Low shear stress increased superoxide production and nitrotyrosine expression. ⺠Low shear stress increased PARP-1 expression and PAR formation. ⺠PARP-1 can be activated by LSS via ERK dependent pathway. ⺠PARP-1 inhibition decreased LSS-induced inflammatory cytokines upregulation by preventing NF-κB nuclear translocation.
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Authors
Wei-dong Qin, Shu-jian Wei, Xu-ping Wang, Juan Wang, Wen-ke Wang, Fuqiang Liu, Lei Gong, Fei Yan, Yun Zhang, Mingxiang Zhang,