Article ID Journal Published Year Pages File Type
10802342 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2013 11 Pages PDF
Abstract
► CaMKIV and Notch1 are required for RANKL-induced osteoclast differentiation. ► Notch1-IC interacts directly with CaMKIV in intact cells. ► CaMKIV up-regulates the Notch1-IC protein stability. ► CaMKIV positively regulates Notch1 signaling through an E3 ligase, Fbw7 ► CaMKIV-mediated phosphorylation of Notch1-IC inhibits the degradation of Notch1-IC.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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Calcium/calmodulin-dependent protein kinase IV (CaMKIV) enhances osteoclast differentiation via the up-regulation of Notch1 protein stability
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