Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10802345 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 12 Pages |
Abstract
⺠Peroxynitrite affects functions of synaptic proteins involved in exo-endocytosis. ⺠Phosphorylated Tyr273 in C-terminal tail of Synaptophysin binds to and activates c-src. ⺠Formation of Synaptophysin/Dynamin I complex is impaired by peroxynitrite. ⺠Peroxynitrite inhibits Dynamin I GTPase activity and self-assembly. ⺠We identified in Dynamin I one nitration site at Tyr354 using MS/MS analysis.
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Authors
Cinzia Mallozzi, Carmen D'Amore, Serena Camerini, Gianfranco Macchia, Marco Crescenzi, Tamara Corinna Petrucci, Anna Maria Michela Di Stasi,