| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802368 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2015 | 12 Pages |
Abstract
⺠The Fox transcription factor Hcm1 translocates to the nucleus by nutrient limitation. ⺠Hcm1 transcriptional activity is activated when both glucose and nitrogen decrease. ⺠Snf1, the yeast AMPK, phosphorylates Hcm1 and increases its nuclear localization. ⺠Tor1/Sch9 pathway negatively regulates Hcm1, promoting its nuclear exclusion. ⺠Hcm1 allows cell adaptation to nutrient deficiency by enhancing oxidative metabolism.
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Authors
MarÃa José RodrÃguez-Colman, M. Alba Sorolla, Núria Vall-llaura, Jordi Tamarit, Joaquim Ros, Elisa Cabiscol,