Glutathione and modulation of cell apoptosis

Article ID	Journal	Published Year	Pages	File Type
10802373	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	2012	11 Pages	PDF

Abstract

âº Death receptor-mediated and mitochondria-mediated pathways as modes of apoptosis. âº Distinct GSH redox pools exist in subcellular organelles within cells. âº Disrupted cellular GSH balance contributes to activation of the apoptotic cascade. âº Formation of S-glutathiolated proteins is important in apoptotic signaling.

Keywords

RIP1 APAf-1 DISC FADD BSO AVD PDI TRAF2 FLIP OGC mitochondrial GSH OATP TRADD VDAC MRP1 PEITC SMAC DIABLO ASK-1 Endonuclease G OMM Dem Ero1 2-Oxoglutarate carrier l-buthionine (S,R)-sulfoximine IMAC GGT Jnk DIC ATO IAP ERK ANT PTP GCL Cyt C UPR c-Jun N-terminal kinase Mitochondrial DNA MAPK MAPK kinase MAPK kinase kinase γ-glutamyl transpeptidase arsenic trioxide apoptotic protease-activating factor-1 Permeability transition pore adenine nucleotide translocase dicarboxylate carrier EndoG apoptotic volume decrease Fas-associated death domain second mitochondria-derived activator of caspases diethyl maleate mtDNA SOD Superoxide dismutase cytochrome c endoplasmic reticulum TNF receptor-associated factor 2 outer mitochondrial membrane glutamate cysteine ligase menadione Mitochondrial membrane potential receptor-interacting protein 1 protein disulfide isomerase Multidrug resistance protein-1 mitogen-activated protein kinase Organic anion transporting polypeptide death-inducing signaling complex Inner membrane anion channel voltage dependent anion channel extracellular signal-regulated kinase Apoptosis signal-regulating kinase-1 glutathione reductase death receptor