| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802379 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 10 Pages |
Abstract
⺠A search for beta-catenin-interacting partners was proposed. ⺠Sox9 and KLF4 transcription factors were revealed to be potent in inhibiting beta-catenin interaction with TCF probe. ⺠Sox9 and KLF4 reduced both TCF-binding and activity in many cancer cells lines. ⺠We are reporting that these transcription factors (Sox9/KLF4) bind to beta-catenin and reduce its interaction with TCF4. ⺠Sox9 and KLF4 are good candidates to suppress tumor progression.
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Authors
Hassan Sellak, Songwei Wu, Thomas M. Lincoln,