Article ID Journal Published Year Pages File Type
10802394 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2012 13 Pages PDF
Abstract
► In kidney cells, Bestrophin-3 is expressed in plasma membrane, nuclei and intracellular compartments. ► Renal Bestrophin-3 is increased by ER stress. ► ER stress-induced Bestrophin-3 expression depends on Ca2+, ROS and ERK. ► Bestrophin-3 enhances cell survival during ER stress. ► Bestrophin 3-dependent cell survival occurs through reduction of pro-apoptotic CHOP.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
ERK1/2-dependent bestrophin-3 expression prevents ER-stress-induced cell death in renal epithelial cells by reducing CHOP
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