| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802396 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 11 Pages |
Abstract
⺠NR4A nuclear orphan receptors are important in vascular disease and metabolism. ⺠Pin1 binds NR4A receptors and enhances their transcriptional activity. ⺠Pin1 increases Nur77, but not Nurr1 or NOR-1 protein stability. ⺠Serine152 is crucial in Pin1-mediated Nur77 protein stability. ⺠This novel regulation mechanism offers new possibilities to manipulate NR4A activity.
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Authors
Claudia M. van Tiel, Kondababu Kurakula, Duco S. Koenis, Erik van der Wal, Carlie J.M. de Vries,