| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802405 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 15 Pages |
Abstract
⺠Prostacyclin plays a central role in hemostasis and vascular re-endothelialization. ⺠IKEPP was discovered as a direct functional interactant of the prostacyclin receptor. ⺠We provide the first evidence that IKEPP is expressed in the vascular endothelium. ⺠IKEPP co-localizes and is associated with the hIP in vascular endothelial cells. ⺠IKEPP regulates prostacyclin-induced endothelial migration and in vitro angiogenesis.
Keywords
NA+/H+ exchange regulatory factorPDZK1Y2HHUVECRBDpKaGPCRQDOPDZNHERFFTidDOInteractionHuman umbilical vein endothelial cellRadioligand binding assayPhosphorylationPhospholipaseyeast-two-hybridHIPFarnesyl transferase inhibitorhemagglutinincAMP-dependent protein kinase AProstacyclin receptorG protein-coupled receptor
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Authors
Helen M. Reid, Elizebeth C. Turner, Eamon P. Mulvaney, Paula B. Hyland, Caitriona McLean, B. Therese Kinsella,