Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10802410 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 13 Pages |
Abstract
⺠3,3â²-diamino-4â²-methoxyflavone (DD1) induces human myeloid tumor-selective apoptosis. ⺠DD1-mediated proteasome inhibition dictates apoptosis. ⺠The mechanism relies on Bax activation and caspase-dependent p70S6 kinase degradation. ⺠Crosstalk by flavone and bortezomib contributes to additive apoptotic effects. ⺠Proteasome inhibition by DD1 could help in overcoming multidrug resistance in tumors.
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Authors
Marion Piedfer, Sandrine Bouchet, Ruoping Tang, Christian Billard, Daniel Dauzonne, Brigitte Bauvois,