Hsp90 inhibition by PU-H71 induces apoptosis through endoplasmic reticulum stress and mitochondrial pathway in cancer cells and overcomes the resistance conferred by Bcl-2

Article ID	Journal	Published Year	Pages	File Type
10802416	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	2013	11 Pages	PDF

Abstract

âº Hsp90 inhibition by PU-H71 induces ER-stress mediated apoptosis in human cancer cells. âº Apoptosis occurs through the mitochondrial pathway and requires Bax. âº PU-H71 exerts no toxicity toward healthy cells. âº PU-H71 overcomes Bcl-2 mediated resistance to apoptosis. âº Combination of PU-H71 and alkylating agents sensitizes resistant cells to apoptosis.

Keywords

MMP vMIA Cisp MLP HSP90 Bcl-2 PU-H71 IP3R Thapsigargin ΔΨm UPR Mitochondrial apoptosis ER stress Bax Room temperature Cancer cisplatin Outer membrane inner membrane melphalan Mitochondrial membrane permeabilization Unfolded protein response Mitochondrial transmembrane potential Heat shock protein 90 Propidium iodide Inositol 1,4,5-triphosphate receptor