| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802424 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 12 Pages |
Abstract
⺠Strong cell adhesion is opposite to cell migration. ⺠Neuronal Thy-1 engages integrin and syndecan-4 in astrocytes to greatly increase their adhesion. ⺠Thy-1 stimulation for 1 h activates Rac1 and inactivates RhoA. ⺠Extended Thy-1 stimulation period triggers the activation of FAK-PI3K-Rac1 signaling pathway. ⺠Neuron-astrocyte binding dorsally engages receptors and signaling molecules to promote cell motility over a substratum.
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Authors
Milene Kong, Nicolás Muñoz, Alejandra Valdivia, Alvaro Alvarez, Rodrigo Herrera-Molina, Areli Cárdenas, Pascal Schneider, Keith Burridge, Andrew F.G. Quest, Lisette Leyton,