| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802428 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 11 Pages |
Abstract
⺠HIPK2 is catalytically activated by activation-loop Y354 autophosphorylation. ⺠Inhibition of HIPK2-Y354 phosphorylation results in out-of-target Y kinase activity. ⺠Out-of-target Y kinase activity delocalizes HIPK2 into cytoplasmic aggresomes. ⺠HIPK2 cytoplasmic aggresomes are reminiscent of similar observations in human cancers.
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Authors
Francesca Siepi, Veronica Gatti, Serena Camerini, Marco Crescenzi, Silvia Soddu,