| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802439 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 15 Pages |
Abstract
⺠The role of ascorbate in transferrin iron (Fe-Tf) uptake is unknown. ⺠Ascorbate stimulates Fe-Tf uptake by a novel intracellular reductive mechanism. ⺠This mechanism is different to ascorbate's role in stimulating non-Tf Fe uptake. ⺠The reductive mechanism involved requires the classical transferrin cycle. ⺠These results are important since cultured cells are typically devoid of ascorbate.
Keywords
BCAIREDesferrioxamineIRPdehydroascorbateGLUTDMT1DcytBCHXBPSduodenal cytochrome BPHEMnTBAPLIPHUVECSFTH1GSHFTLDFOo-PhenanthrolineMnTMPyPFeTMPyPBSAbovine serum albuminiron-regulatory proteinLabile iron poolChobicinchoninic acidChinese Hamster OvaryDiferric transferrinbathophenanthroline disulfonateDHAFerritin Heavy ChainFerritin Light ChainHuman umbilical vein endothelial cellscycloheximideiron-responsive elementreduced glutathionefacilitative glucose transporter
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Authors
Darius J.R. Lane, Sherin Chikhani, Vera Richardson, Des R. Richardson,