| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802452 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 8 Pages |
Abstract
⺠(R)-α-lipoic acid acts as a mild stressor to induce the transcription factor Nrf2. ⺠Stress-induced increase in nuclear Nrf2 doesn't draw solely from pre-existing pool. ⺠De novo translation of Nrf2 rapidly ensues after a lipoic acid stimulus. ⺠Lipoic acid induces Nrf2 protein expression via an IRES, even under mTOR inhibition.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Kate Petersen Shay, Alexander J. Michels, Wenge Li, Ah-Ng Tony Kong, Tory M. Hagen,