Article ID Journal Published Year Pages File Type
10802453 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2012 9 Pages PDF
Abstract
► Claudin-2 is expressed in human lung adenocarcinoma. ► Secreted epidermal growth factor increases claudin-2 expression. ► Claudin-2 expression is regulated by an EGFR/MEK/ERK/c-Fos pathway. ► Transcriptional activity of claudin-2 is inhibited by c-Fos siRNA. ► c-Fos binds to promoter region of claudin-2.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells
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