| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802458 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 12 Pages |
Abstract
⺠We investigate the influence of a pre-existing neutrophilic inflammation on airway epithelial defense. ⺠Neutrophils increase IL-8 and ROS productions by human lung epithelial cells. ⺠The interaction involves ERK1/2 and NF-κB signaling in the epithelial cells. ⺠The interaction depends on a functional neutrophilic NADPH oxidase. ⺠Neutrophilic inflammation augments the response to inflammatory triggers.
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Authors
Agnes W. Boots, Kirsten Gerloff, Roger Bartholomé, Damien van Berlo, Kirstin Ledermann, Guido R.M.M. Haenen, Aalt Bast, Frederik-Jan van Schooten, Catrin Albrecht, Roel P.F. Schins,