| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802459 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 7 Pages |
Abstract
âºThe patch-clamp experiments were performed in the thick ascending limb (TAL). âºApplication of 200 nM IGF-1 inhibited the basolateral Cl channels in the TAL. âºThe basolateral Cl channel is a rate limiting step for Cl exit in the TAL cells. âºRising intracellular Cl level leads to inhibition of trans-cellular Cl transport. âºIGF-1 at high concentration may inhibit epithelial transport in the TAL.
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Authors
Lijun Wang, Wennan Li, Shumin Kong, Peng Wu, Chengbiao Zhang, Li Gu, Mingxiao Wang, WenHui Wang, Ruimin Gu,