| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802461 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 14 Pages |
Abstract
⺠The BBSome-associated protein ARL6 localises to vesicles in Trypanosoma brucei. ⺠T. brucei ARL6 is N-myristoylated. ⺠RNAi knockdown causes a decrease in flagellum length but does not affect motility. ⺠TbARL6 binds to tubulin and has a relatively low affinity for guanine nucleotides. ⺠The BBSome subunit BBS1 and ARL6 are functionally linked in trypanosomes.
Keywords
nESN-methylanthraniloylRP2Pcm1IFTmyristoyl-CoA:protein N-myristoyltransferaseNMTConAGEFBBSomeARFARLPCFNLSMAP2BBSBSFConcanavalin APFRGPCRTrypanosoma bruceiITCG-protein coupled receptorRNA interferenceRNAiTandem affinity purificationtubulinintraflagellar transportBardet–Biedl syndromenuclear export signalnuclear localisation signalTAPPlasma membraneADP-ribosylation factorguanine nucleotide exchange factorbloodstream formprocyclic formMANTParaflagellar rodMicrotubule associated protein 2FlagellumIsothermal titration calorimetry
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Authors
Helen P. Price, Michael R. Hodgkinson, Megan H. Wright, Edward W. Tate, Barbara A. Smith, Mark Carrington, Meg Stark, Deborah F. Smith,