| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802469 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 13 Pages |
Abstract
⺠Mitochondrial morphology is controlled by fusion and fission. ⺠Dynamin-related protein 1 (Drp1) mediates mitochondrial fission. ⺠Mitochondrial fission plays an important role in apoptosis and mitochondrial quality control. ⺠Drp1 is regulated by various post-translational modifications. ⺠Mitochondrial fission deficiencies cause various human diseases.
Keywords
MiD51Endophilin B1SUMOMEFGTPase effector domainGFPMFFGDAP1MFN2Drp1LRRK2pKaGEDRNA interferenceRNAipost-translational modificationNeurodegenerative diseaseMitochondrial fissionleucine-rich repeat kinase 2ApoptosisVariable domainendoplasmic reticulummitochondrial outer membraneMitochondrial inner membranemitochondrial fission factorMoMMIMmouse embryonic fibroblastMitophagymitofusin 2knockoutNitric oxidegreen fluorescent proteincAMP-dependent protein kinasesmall ubiquitin-like modifier
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Authors
Hidenori Otera, Naotada Ishihara, Katsuyoshi Mihara,