Article ID Journal Published Year Pages File Type
10802471 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2013 10 Pages PDF
Abstract
► CCN4 was highly expressed in OA synovial fibroblasts as compared to normal SFs. ► CCN4 induces the monocyte adhesion in OASFs by up-regulation of VCAM-1 expression. ► CCN4 acts through the αvβ5/α6β1 integrin, Syk, PKCδ, and JNK pathways to induce VCAM-1. ► AP-1 is key transcription factor of CCN4-induced VCAM-1 expression.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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CCN4 induces vascular cell adhesion molecule-1 expression in human synovial fibroblasts and promotes monocyte adhesion
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